Thought it'd be nice to compile something like this. If you happen to know any more good ones (especially those with good content but not as well known), let me know and I'll add them to this thread.
**Update:** Added a lot more channels. Almost hitting the character limit now, actually.
**General**
* Valve [Link](https://www.youtube.com/channel/UCg0FSqPeiGD_lIiPaaAehQg)
* GosuGamers [Link](https://www.youtube.com/user/gosugamersnet)
* DotaCinema [Link](https://www.youtube.com/user/DotaCinema)
* DotaFX [Link](https://www.youtube.com/user/DotaFX)
* Dota 2 Portal TV [Link](https://www.youtube.com/user/Dota2PortalTV)
* Coffee w/ Toffees [Link](https://www.youtube.com/channel/UC38iukM4g5jpGhpyaNa0_2Q)
* ChallengingChannel [Link](https://www.youtube.com/user/challengingchannel)
* JoinDOTA Plus [Link](https://www.youtube.com/user/joinDOTAplus)
* Soe [Link](https://www.youtube.com/channel/UCsWIcwE5pPqjCwfA0vcKmUQ)
* Wykrhm [Link](https://www.youtube.com/user/wykrhm)
**Comedy (dank memes)**
* SirActionSlacks [Link](https://www.youtube.com/user/SirActionSlacks1)
* COMBO WAKAMAKA [Link](https://www.youtube.com/user/larsroar92)
* Krokodainer [Link](https://www.youtube.com/user/krokodainer)
* Nigma [Link](https://www.youtube.com/user/nigmanoname)
* TryMike4Instance [Link](https://www.youtube.com/user/TryMike4instance)
* Dota 420 [Link](https://www.youtube.com/user/TheMugiwara12)
* JimBenDoto [Link](https://www.youtube.com/user/jimsworlddota)
* JukesOfHazzard [Link](https://www.youtube.com/channel/UCPPHrB8mMepKmM4OiSAtUdA)
* PyrionFlax [Link](https://www.youtube.com/user/tedhimself)
* BigPlaysInc [Link](https://www.youtube.com/user/BigPlaysIncPresents)
* Dota Poop [Link](https://www.youtube.com/user/Dotapoop69)
* Dota WTF [Link](https://www.youtube.com/user/DarduinMyMenlon)
* Refleksy [Link](https://www.youtube.com/channel/UCpL5BwszPKh3KapRfTd0dRw)
* RatchetPo [Link](https://www.youtube.com/user/RatchetPo)
* Mid or Meepo (relatively new) [Link](https://www.youtube.com/channel/UCFewCocoHBUpnPmMi-rucog)
* Meed&Fid (relatively new) [Link](https://www.youtube.com/channel/UCuwVUex5VmAHvTrku_azKeg)
* DeethzPlays (relatively new) [Link](https://www.youtube.com/channel/UCYfWn1JCF5j1qjORrjTJUqw)
**Real Life**
* TSBR (Dota Shitty Cosplays) [Link](https://www.youtube.com/channel/UCX5LMU6sZ0y1CJxbt0wMUFQ)
* DotaMe (Live action sitcom) [Link](https://www.youtube.com/channel/UCdbnnW4be4FrKlNySFIPCRw)
**Cartoons**
* Wronchi (Dota 2 Reporter series) [Link](https://www.youtube.com/user/WronchiAnimation)
* RockSoftCookie (super cute animations) [Link](https://www.youtube.com/user/RockSoftCookie)
* Dopatwo [Link](https://www.youtube.com/user/dopatwo)
* Lesllee (Play Like ____ animations) [Link](https://www.youtube.com/channel/UCBdeLc3WC-BCVWDOpyR6zmw)
* DrunkAnimations [Link](https://www.youtube.com/channel/UCh-JpncnKLBtlY31XX4vgJQ)
* OldBrockCinema [Link](https://www.youtube.com/channel/UCTqt7pKBkoW4QN32mNzY0rA)
* PoisonRune [Link](https://www.youtube.com/channel/UCLWrd0ltP63vkW_lBpyGDeQ)
* Toonhaze [Link](https://www.youtube.com/user/toonhaze)
* CAPSLOCKFURY [Link](https://www.youtube.com/channel/UCTnrmaLax4iklsMUyLdjVJw)
* GroovyGoblin (Void goes farming) [Link](https://www.youtube.com/user/GroovyGoblinLabs)
* Beebop Animations [Link](https://www.youtube.com/channel/UCcHOu0ABuPJoE4ZuazL9YJQ)
* C Michael Broyles (GG Well Played series) [Link](https://www.youtube.com/channel/UCrWd5w9_qfzn0wQrNyNtheg)
**Stream highlights (Comedy)**
* GotChaDotA [Link](https://www.youtube.com/user/GotChaDotA)
* MagikarpDota [Link](https://www.youtube.com/channel/UCoXNoZVLMMcLhUn0bfzXF2g)
* Gumbot Casper [Link](https://www.youtube.com/channel/UCOSF_M9OE8CXPhdMI6ezJMg)
* Trax1 [Link](https://www.youtube.com/channel/UCY1yMUr-l1VBx2S-7KVrVNQ)
**Official pro player channels**
* PPD [Link](https://www.youtube.com/user/peterpandam)
* EternalEnvy [Link](https://www.youtube.com/user/EternaLEnVy)
* SingSing [Link](https://www.youtube.com/user/WehSing)
* Aui_2000 [Link](https://www.youtube.com/user/KurtisLing)
* AdmiralBulldog [Link](https://www.youtube.com/channel/UCk8ZIMJxSO9-pUg7xyrnaFQ)
* s4 [Link](https://www.youtube.com/channel/UCpLWL3pl9Ss9olsHRChhSrw)
* FLUFFANDSTUFF [Link](https://www.youtube.com/channel/UCbSQNvBbk_hhZqniBow5RwA)
* Jenkins [Link](https://www.youtube.com/channel/UCTUO_3bYr50vmH0aE7byMjg)
* Dread [Link](https://www.youtube.com/user/DreadShow)
* iceiceice [Link](https://www.youtube.com/channel/UCEr60Nt_St7UcdllX3J0BVA)
**Unconfirmed/fanmade pro player VODs channels**
* Solo [Link](https://www.youtube.com/user/SoloStreamVideos)
* Aui_2000 VODs [Link](https://www.youtube.com/channel/UCihipunrDtH2AZy90wsXVFQ/videos)
* SingSing VODs [Link](https://www.youtube.com/user/jan20118909)
* Suma1l [Link](https://www.youtube.com/channel/UC2CWH48I-um5xeOFoNOYltQ)
* Team Secret [Link](https://www.youtube.com/channel/UCOjYpdIKbXAi52XgKQ3kK0g)
* Fear [Link](https://www.youtube.com/channel/UCgydTARh-x3ZlZEC46NycCQ)
* Dendi [Link](https://www.youtube.com/user/NatusVincereDendi)
* Arteezy [Link](https://www.youtube.com/user/dota2arteezy/)
* Up 2 Dota [Link](https://www.youtube.com/user/up2dota)
* Best Dota 2 [Link](https://www.youtube.com/channel/UCn6S357Qavdbjccl0YCfqjg)
* Dota 2 Pro [Link](https://www.youtube.com/user/Dota2ProChannels)
* EverydayFrags [Link](https://www.youtube.com/user/everydayfrags)
**Educational**
* Merlini [Link](https://www.youtube.com/user/MerliniDota)
* Blitz [Link](https://www.youtube.com/channel/UCLJdA8ZCxCkY_XxDCnyAjSg)
* Purge [Link](https://www.youtube.com/user/PurgeGamers)
* Slahser [Link](https://www.youtube.com/user/slahserTV)
* Wagamama [Link](https://www.youtube.com/user/WagaGaming)
* BananaSlamJamma [Link](https://www.youtube.com/channel/UCvTcxoyItMUSlw8T2MajftA)
* Myzzrym [Link](https://www.youtube.com/channel/UC189DRu1QhU4VfSHvrx4Sng)
* GoodGoodNotGreat [Link](https://www.youtube.com/user/GGNGDota)
* Prove Reviews [Link](https://www.youtube.com/channel/UCMbKhl9nvgCJ1hGoWR-pIdg)
* DemigodDota [Link](http://www.youtube.com/user/DemigodDota)
* ProfessorFiercE [Link](https://www.youtube.com/channel/UC7Yevl5e1gqot8kdOt25VKQ)
* SimplyDota [Link](https://www.youtube.com/channel/UCOrqfaaWzpo6ALaVM08rNWA)
* Luminous [Link](https://www.youtube.com/user/LuminousInverse)
* PhysicsMathMan [Link](https://www.youtube.com/user/PhysicsMathMan)
* Relax You're Fine (Luminous+dpmlicious+PhysicsMathMan+Tsunami643) [Link](https://www.youtube.com/channel/UCeo_5MdWEaO6CTYvZHqEDrQ)
* Dota Laboratory [Link](https://www.youtube.com/user/pro100walkman)
* CyberPowerPC (Some guides featuring CoL players) [Link](https://www.youtube.com/user/cyberpowerpcinc/search?query=CoL.D2)
* Dota D.Bowie [Link](https://www.youtube.com/user/D2BOWIE)
* Bren Dota [Link](https://www.youtube.com/user/BrenGaming1)
* ButcherTV (Great advanced Pudge guides) [Link](https://www.youtube.com/user/yeayeayea1100)
* Mackcowanii (Jungle guides) [Link](https://www.youtube.com/user/mackcowanii/)
* Magikk (Tiny+Wisp and general Wisp plays/guides) [Link](https://www.youtube.com/channel/UCsHmU_KkVlHk76b4BTk1MBA)
* LAZY GRASSHOPPER (fundamentals tips) [Link](https://www.youtube.com/channel/UCm1OJNsJt-PwDf2O1hLqYIw)
* Geno [Link](https://www.youtube.com/user/GenoGaming)
* YorgYetson (Micro w/o Control Groups series) [Link](https://www.youtube.com/user/YorgYetson)
* Xeonus [Link](https://www.youtube.com/user/Xeonusify)
* Quadron [Link](https://www.youtube.com/playlist?list=PLox464babK13R70iPuJwOfm3f9Wd0RXFI)
**User Plays <Hero>**
* Grimorum [Link](https://www.youtube.com/user/legitxeris/)
* Baumi [Link](https://www.youtube.com/user/l34Um1)
* DannyGaminGnC [Link](https://www.youtube.com/user/DannyGaminGnC)
* ChiLongQua [Link](https://www.youtube.com/user/ChiLongQua)
* Gulius112 (Basically I played ____) [Link](https://www.youtube.com/user/gulius112)
* Wicked Sick TV (EEL player stacks with Resolut1on, Solo, Dread,etc)(Speaks Russian) [Link](http://www.youtube.com/channel/UClYdIL9hlAbSlUTexMLrpmQ)
**Casters**
* Luminous [Link](https://www.youtube.com/user/LuminousInverse)
* LD [Link](https://www.youtube.com/user/ldDOTA)
* GoDz [Link](https://www.youtube.com/user/GoDzStudios)
* Sheever [Link](https://www.youtube.com/user/SheeverGaming)
* Zyori [Link](https://www.youtube.com/user/ZyoriTV1)
* Rusts [Link](https://www.youtube.com/channel/UC17MCBNrMRs6Yp5cClGKJKA)
* PimpmuckL [Link](https://www.youtube.com/channel/UCemas8D9XEsfHI4eh7PHxAg)
**RIP-old-school-I-wonder-what-they're-doing-now Casters**
* IanJamesBarnett [Link](https://www.youtube.com/user/ianjamesbarnett)
* Bbalin773 [Link](https://www.youtube.com/user/Bballin773)
**Studios**
* BeyondTheSummit [Link](https://www.youtube.com/user/beyondthesummittv)
* JoinDota [Link](https://www.youtube.com/user/joinDOTA)
* HighGround TV [Link](https://www.youtube.com/user/HighGroundTV)
* GD Studio [Link](http://www.youtube.com/channel/UCephVCPj97LWTeGagjlsPWQ)
* HeflaTV [Link](http://www.youtube.com/user/Heflamoke)
* Storm Studios (LoH, Maelstorm) [Link](https://www.youtube.com/channel/UCpPpXo2ATn0BQsMpCTTI0yg)
* Truesight TV (new studio) [Link](https://www.youtube.com/channel/UCTrqKpGLECSkkWRnxOtilNA)
**Tournaments**
* D2L [Link](https://www.youtube.com/channel/UCkOAwX4gdf-iJ2ZTs6axVnw)
* Dota 2 Champions League [Link](https://www.youtube.com/channel/UCvxjDcY-BcHsasNAQq06j1A)
* Starladder [Link](https://www.youtube.com/user/dotasltv)
* DreamLeague [Link](https://www.youtube.com/channel/UC5jm7vq-8YUjCYKh_JysFPw)
* American Dota League [Link](https://www.youtube.com/user/AmericanDotaLeague)
* XMG Captains Draft (DotaCinema) [Link](https://www.youtube.com/channel/UC20bQQhVzceuQMn8zJL2i-A)
* Dota 2 Canada Cup [Link](https://www.youtube.com/channel/UCLBmpNLgNowYxzy82JbD9jg)
**Highlights**
* NoobFromUA [Link](https://www.youtube.com/user/noobfromua)
* MidasHim [Link](https://www.youtube.com/user/MidasHim)
* diesmiling666 [Link](https://www.youtube.com/user/diesmiling666)
* Widdz [Link](https://www.youtube.com/channel/UC1h4ld2anwjT4NEbqFOJRXQ)
* DoubleClickDota2 [Link](https://www.youtube.com/user/DoubleClickDota2)
* HolyHexor [Link](https://www.youtube.com/user/hOlyhexOr)
* ProDOTAtvFromRUSSIA [Link](https://www.youtube.com/user/9xXxNikitAxXx9)
* DotaArchive [Link](https://www.youtube.com/user/DotaArchive)
* jackreacherdota [Link](https://www.youtube.com/user/jackreacherdota)
* OnlyBrothersGamers [Link](https://www.youtube.com/user/OnlyBrothersGamers/videos)
* WoDotA [Link](https://www.youtube.com/channel/UCtGaB9b1-eE-GeuMguCbdkA)
**Pro Teams**
* Na'Vi [Link](https://www.youtube.com/user/natusvinceretv)
* Empire [Link](https://www.youtube.com/channel/UCibYFNNSV13CH64R44fIfZw)
* Alliance (Note: They upload LoL clips here as well.) [Link](https://www.youtube.com/user/theAllianceGG)
* LGD [Link](https://www.youtube.com/user/LGDGamingTV)
**Moviemakers**
* Blurplurp [Link](https://www.youtube.com/user/Blurplurp)
* Myn Editor [Link](https://www.youtube.com/channel/UCvSZpdMCKCTDWLnQgacYbtA)
* -ExotiC- [Link](https://www.youtube.com/channel/UCamWcApPWQN8ebtaPXYsUZQ)
* 4fun911 [Link](https://www.youtube.com/user/4fun911)
**SFM**
* swordzzzzz [Link](https://www.youtube.com/user/swordzzzzz)
* EDJE [Link](https://www.youtube.com/user/xxEDJExx)
* XepocuH [Link](https://www.youtube.com/user/XepocuH)
* MaritimeTR [Link](https://www.youtube.com/channel/UCqoFXdyN4xW8d0ygIuiKC1g)
* Dota2VO [English Link](https://www.youtube.com/user/dota2voeng) [Russian Link](https://www.youtube.com/user/dota2voru)
* Drew Carrymore [Link](https://www.youtube.com/channel/UCNW74oOObmC0d4aac8iK6dw)
* MrMrpounder [Link](https://www.youtube.com/channel/UCIPOtRHvxfHvtjWUdxirWxA)
* P-o-rtability [Link](https://www.youtube.com/channel/UCA6g0i7FU3WHaKezzDPBxTg)
* Palingenesie [Link](https://www.youtube.com/channel/UCID85epFay-mm8MkELyEfjw)
* Evil Montage [Link](https://www.youtube.com/user/TheEvilGeniy)
* ABSTR [Link](https://www.youtube.com/channel/UCfaIaSlK0t1OfWtPs6EW0Yg)
* TheSpunkyNipple [Link](https://www.youtube.com/user/TheSpunkyNipple/videos)
* VeVita Games [Link](https://www.youtube.com/channel/UC8ETPmC1szisV3Fomp1oDLw)
* FrozenShield [Link](https://www.youtube.com/user/FrozenShield/videos)
* Blanty [Link](https://www.youtube.com/channel/UC5ITbQIrs-OEYMlPSBZjbZA)
* BOLT [Link](https://www.youtube.com/channel/UCROBwiCpAQ-LT0fbsK6AHJw)
* HTML_EARTH [Link](https://www.youtube.com/channel/UC1i6192yq6TcRG8KrInObwg)
* Jonny212 [Link](https://www.youtube.com/user/jonny212/featured)
* Lozeng3r [Link](https://www.youtube.com/channel/UCtSDMNYyHq_84lIm9EBPjnA)
* MayorPixel [Link](https://www.youtube.com/user/MayorPixel/videos)
**Music**
* Pumodi (New Bloom sound guy) [Link](https://www.youtube.com/user/jeffreybricemusic)
* HLGF [Link](https://www.youtube.com/user/haveluckgoodfun)
* Fwosh [Link](https://www.youtube.com/user/fwosh)
* Refresher Parodies [Link](https://www.youtube.com/user/RefresherParodies)
* SadOnionDota [Link](https://www.youtube.com/user/SadOnionDota)
* BracerCrane [Link](https://www.youtube.com/playlist?list=PLwUpHT7RO60LZ-m93WH5uNKcqOqndfk2b)
* xCirrex (Rap Battles) [Link](https://www.youtube.com/channel/UCZGb6g-9s4fMnjms43Qgh_A)
* Arathrum (Dota 2 Metal) [Link](https://www.youtube.com/channel/UCNXZ4kjORj4mFjP6d4QCkQg)
**Non-English channels**
* Purple Dog (Portugese) [Link](https://www.youtube.com/channel/UCEXL2rLQjvPQwhiCZXg5SdQ)
* Veteranonoob (Portugese) [Link](https://www.youtube.com/user/VeteranoNoob)
* Mazoku Dota (Spanish) [Link](https://www.youtube.com/user/AprendiendoDota)
* MetaGame (Russian) [Link](https://www.youtube.com/user/MetaGameRus)
* AraDota (Russian) [Link](https://www.youtube.com/user/AraGamesReview)
* VEB DOTA (Polish) [Link](https://www.youtube.com/user/VEBDOTA)
* Nomad Dota 2 (Brazilian) [Link](https://www.youtube.com/user/nomadTVDota2)
* 新號 (Chinese) [Link](https://www.youtube.com/channel/UC_d3lXj52Gu14i9hSVIzsIw)
* 游戏中国 (Chinese) [Link](https://www.youtube.com/channel/UCDrxIKg6-BdqTeEKVZbrlJA)
**Modding**
* ShutnikMods [Link](https://www.youtube.com/channel/UCR9QLvUJk-t15_JaZ1lv9Lw)
* CyborgMatt [Link](https://www.youtube.com/channel/UCe3QZ0CBLNZeHV-luMp1KEA)
**Workshop Artists**
* Live Workshop [Link](https://www.youtube.com/user/DigitalLiveWorkshop)
* C-legFX [Link](https://www.youtube.com/user/achrislefilm/videos)
* Danidem [Link](https://www.youtube.com/user/TheDanidem/videos)
* Red Moon Workshop [Link](https://www.youtube.com/channel/UCfBGXzNLhEyuxzBRK2OthbA)
* Thiago Vidotto [Link](https://www.youtube.com/channel/UCG7nr_tItVPf0D2xHGV8EOw)
* 黄贻睿/K-Pax [Link](https://www.youtube.com/channel/UCgDvkFpC_UcHwLrOtyTlwUA)
**Speed painting**
* Trung Th [Link](https://www.youtube.com/channel/UC9qJ0zjqHxjY-nRcWu38YtA)
**Hats**
* Dota Trade [Link](https://www.youtube.com/user/dota2itemstrade)
* Feeder [Link](https://www.youtube.com/user/dota2feedernoob)