, it is now known Nerve renew a whole series of endogenous mechanisms influence our experience of pain. These excitatory and inhibitory mechanisms may increase or reduce the nociceptive signal Nerve renew translates into more or less intense pain.9 So how does this process begin? To answer this question we need to introduce the term transduction: the process by which the energy of a stimulus is transformed into an electrical response. How does the energy of a stimulus transfer into an electrical response? According to current thinking, the nociceptor has more than one transduction mechanism Nerve renew result from direct excitation or through receptor cells. Continuous painful stimulation