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Commercially popular apple cultivars are soft but crisp. Role of NK cell subsets in organ-specific murine melanoma metastasis. J Exp Med 209 10 :1869-82. Exp Hematol 35 4 :682-90.
J Exp Med 206 6 :1423-34. J Immunol 190 12 :6694-706.
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Also Known As: NOD- Rag1 null IL2rg null, NOD rag gamma, NRG These mice are most commonly called NRG and are extremely immunodeficient. The Rag1 null mutation renders the mice B and T cell deficient and the IL2rg null mutation prevents cytokine signaling through multiple receptors, leading to a deficiency in functional NK cells. The severe immunodeficiency allows the mice to be humanized by engraftment of human CD34+ hematopoietic stem cells HSC and patient derived xenografts PDX at high efficiency. The immunodeficient NRG mice are more resistant to irradiation and genotoxic drugs than mice with a scid mutation in the DNA repair enzyme Prkdc. Donating Investigator These NRG mice are NOD-congenic mice harboring the Rag1 null mutation Rag1KO or Rag1 tm1Mom on chromosome 2 and the IL2rγ null mutation IL2RγcKO or Il2rg tm1Wjl on the X chromosome. These NRG mutant mice are also called NOD- Rag1 null IL2rγ null double mutant mice or NOD. Females homozygous for both mutations and males homozygous for Rag1 null; hemizygous for the X-linked IL2rγ null mutation are viable and fertile. When compared to NOD- scid IL2rg null mice NSG mice; Stock No. Additionally, NRG mice support higher levels of both human cord blood stem cell engraftment following irradiation-conditioning leading to multi-lineage hematopoietic cell populations and a complete repertoire of human immune cells, including human T cells and human peripheral blood mononuclear cells engraftment in unconditioned adult mice with respect to NOD- Rag1 null Stock No. These NRG mice may be useful for cell or tissue transplantation studies, particularly as a model for human lymphohematopoietic cell engraftment studies that require a radioresistant host. These NRG mice are NOD-congenic mice harboring the Rag1 null mutation Rag1KO or Rag1 tm1Mom on chromosome 2 and the IL2rγ null mutation IL2RγcKO or Il2rg tm1Wjl on the X chromosome. These NRG mutant mice also called NOD- Rag1 null IL2rγ null double mutant mice or NOD. IL2RγcKO mice were produced by breeding NOD- Rag1 null Stock No. Offspring were intercrossed and bred to be homozygous for the Rag1 null mutation, homozygous for females; or hemizygous for males for the X-linked IL2rγ null mutation, and wild-type for the scid mutation. The donating investigator reports that the genetic background is equivalent to approximately N9 prior to arrival at The Jackson Laboratory Repository. Non-obese diabetic-recombination activating gene-1 NOD-Rag1 null interleukin IL -2 receptor common gamma chain IL2r gamma null null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol 154 2 :270-84. Mutations Made By Dr. A mutant transcript expressed from this allele was detected by Northern blot in bone marrow derived cell lines from homozygous mice. 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